There is an outbred population of mice living in a farmer’s field. Mutations occur at a gene called nurseryrhyme that cause a totally recessive form of blindness (h=0). These blind mice do not survive to reproduce because the farmer’s wife cuts off their tail (and other bits) with a carving knife. Surveying the field for baby mice you find that 3/10,000 mice are blind. A. Assuming that the population mates at random, what is the mutation rate of blindness causing alleles? B. Following more careful study you now find that there is actually a 20% reduction in the viability of heterozygotes for these mutations. What would you now estimate as the mutation rate for this gene?

There is an outbred population of mice living in a farmer’s field. Mutations occur at a gene called nurseryrhyme that cause a totally recessive form of blindness (h=0). These blind mice do not survive to reproduce because the farmer’s wife cuts off their tail (and other bits) with a carving knife. Surveying the field for baby mice you find that 3/10,000 mice are blind. A. Assuming that the population mates at random, what is the mutation rate of blindness causing alleles? B. Following more careful study you now find that there is actually a 20% reduction in the viability of heterozygotes for these mutations. What would you now estimate as the mutation rate for this gene?

Human Heredity: Principles and Issues (MindTap Course List)

11th Edition

ISBN:9781305251052

Author:Michael Cummings

Publisher:Michael Cummings

Chapter19: Population Genetics And Human Evolution

Section: Chapter Questions

Problem 11QP: Using the HardyWeinberg Law in Human Genetics In a given population, the frequencies of the four...

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