A phenotypically normal couple has had one normal child and one child with cystic fibrosis, an autosomal recessive disease. What are the genotypes of the parents? What is the chance that their next child will be a carrier of cystic fibrosis

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Description: A phenotypically normal couple has had one normal child and one child with cystic fibrosis, an autosomal recessive disease. What are the genotypes of the parents? What is the chance that their next child will be a carrier of cystic fibrosis?Many rece

Human Heredity: Principles and Issues (MindTap Course List)

11th Edition

ISBN:9781305251052

Author:Michael Cummings

Publisher:Michael Cummings

Chapter18: Genetics Of Behavior

Section: Chapter Questions

Problem 14QP: A pedigree analysis was performed on the family of a man with schizophrenia. Based on the known...

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The young woman shown at right has albinismvery pale skin, white hair, and pale blue eyes. This phenotype is due to the absence of melanin, which imparts color to the skin, hair, and eyes. It typically is caused by a recessive allele. In the following situations, what are the probable genotypes of the father, the mother, and their children? a. Both parents have normal phenotypes; some of their children are albino and others are not. b. Both parents and all their children are albino. c. The mother is not albino, the father is albino, and one of their four children is albino.
In the USA the frequency of carriers for the devastating autosomal recessive trait of procrastination is 1/10 people. You do not procrastinate and want to have a child with another highly efficient non-procrastinator. You are worried that you both might be carriers and that your child would be a procrastinator. What is the probability that you are a carrier, AND your mate is a carrier, AND your child is procrastinator?
in humans, normal skin pigmentation is influenced by a dominant gene (c), which allows pigmentation to develop. all individuals who are homozygous for the recessive allele (c) are unable to produce an enzyme needed for melanin formation and are therefore referred to as albino. two normal parents produce an albino child. what are the chances that the next child will be an albino? 1/2 chance 1/8 chance 2/3 chance no chance 1/4 chance
Cystic fibrosis in humans is caused by a recessive allele. A man is known to be a carrier of the cystic fibrosis allele. He marries a phenotypically normal woman. In the general population, the incidence of cystic fibrosis at birth is approximately 1 in 1,700. Assume Hardy-Weinberg proportions. What is the probability that the wife is also a carrier? Answer in decimal number only (three decimal places; example: 0.123). What is the probability that their first child will be affected? Answer in decimal number only (three decimal places; example: 0.123).
The incidence of a rare autosomal recessive genetic disorder, Tay-Sachs, is approximately 1 in 3,500 in a certain population. Assuming that this population is in Hardy-Weinberg equilibrium, what is the probability that a phenotypically normal female with no family history, and a phenotypically normal male who had an affected great-aunt, will have a child who is a carrier for Tay-Sachs?
Polydactyly is an autosomal dominant trait that results in the presence of additional digits on the hands and feet. The incidence in Caucasians is approximately 1 in every 1300 births while in Africans and African Americans, the prevalence is 1 in every ~150 births. Fortunately, this trait does not cause any deleterious effects on one's health. Actually, there are a number of individuals who have been successful football players that were born with polydactyly. In 1902, a study found that the allele frequency of the recessive allele (p) was 30% in the local population. Last year, a follow-up study was published which assessed the genotypes of the same local population. The following data were obtained: pp = 10%; Pp = 40%; PP = 50% Use the above information to answer the questions below. Use the word bank for a subquestion when provided. What is the frequency of p (recessive allele) in the follow-up study? Round your answer to the nearest tenth. Did the population evolve?…
Six single-nucleotide polymorphism (SNP) loci are known to contribute to the development of type 2 diabetes. Diabetes is certain if eight or more of the alleles at these six loci are of the “contributing” variety. An uppercase letter indicates an allele that contributes to diabetes and a lowercase symbol indicates a noncontributing allele. A married couple wants to know the probability of producing a child who is at severe risk of type 2 diabetes. Their genotypes were determined by microarray analysis and are as follows: AaBbccDDEEFf × AaBbCCDdEeFf
Cystic Fibrosis (CF) is an autosomal recessive condition. Therefore, heterozygous (Cc) carriers do not display symptoms. Two parents who are carriers plan to start a family and you are a genetic counselor helping to advise them about their chances of having children affected by CF. a) Suppose the couple has 4 children, each one year apart. What is the probability that all 4 children will inherit CF? b) What is the probability that any 3 of their 4 children will not inherit CF, but 1 will be affected? c) What is the probability that their first child will not inherit CF, but the younger 3 children will inherit CF?
Albinism is an autosomal (not sex-linked) recessive trait. A man and woman are both of normal pigmentation and have one child out of three who is albino (without melanin pigmentation). What are the genotypes of the albino's parents? Both parents must be homozygous dominant. Both parents must be heterozygous. One parent must be homozygous dominant; the other parent must be heterozygous. One parent must be heterozygous; the other parent can be homozygous dominant, homozygous recessive, or heterozygous. One parent must be homozygous for the recessive allele; the other parent can be homozygous dominant, homozygous recessive, or heterozygous. O O O O O
Refsum disease is a genetic disorder that is inherited in an autosomal recessive pattern. Individuals with adult Refsum disease do not have the enzyme to breakdown phytanic acid. As a result, phytanic acid accumulates in the brain, blood, and body tissues. As the disease progresses, individuals with Refsum disease experience loss of vision, hearing, and sense of smell, as well as balance and coordination problems.In a population, the frequency of the recessive allele for Refsum disease is 0.28. What is the expected frequency of the carriers in this population? Show all your work. Record your answer as a value between 0 and 1 rounded to two decimal places.
When phenylalanine is converted to phenylpyruvic acid, this molecule accumulates in the body and leads to a disorder known as phenylketonuria (PKU). PKU is due to the expression of a recessive allele,p. If both parents are heterozygous at the PKU locus, what is the probability of having first two affected children and then a normal child? Write the answer in the form 2!/1!1! *
Hemophilia is a recessive sex-linked trait in humans. Sickle-cell anemia is a recessive trait on an autosome. A couple are both carriers of the sickle-cell trait. The man and woman are normal, but the woman is a carrier for hemophilia. How many of their male children would you expect to have both sickle-cell anemia and hemophilia? How many of their female children would have both conditions?